Academic studies

Academic studies
  • Pain in the PACU: Comparison of pain management methods in the PACU and determination of a limit for analgesic administration.

Proper treatment of postoperative pain is only possible if the patient's pain experience is correctly assessed.
The purpose of this study is to identify the correlation between three measurement methods after waking up from anaesthesia and to determine the threshold for the administration of mild or powerful pain medications. This could help optimise postoperative pain management in the future.

Principle investigator: Dr Rik Nieuwenhuizen
Research Centre: Maria Middelares General Hospital

  • Diep-Flap Effect of phenylephrine versus norepinephrin on venous return with a DIEP flap

The primary objective of the study is to evaluate the effect of two different medications that raise blood pressure (phenylephrine vs. norepinephrine) on the return flow of blood to the heart. These are two medications that have been used routinely for decades, and are also used daily
for many of the patients in our hospital.

Phase 4
Principle investigator: Dr Silvie Allaert
Research Centre: Maria Middelares General Hospital

  • SAPB Serratus Anterior Plane Block for Minimally Invasive Cardiac Surgery

The purpose of the study is to assess the analgesic effect of an Anterior Serratus block in minimally invasive cardiosurgical procedures as compared to a control group.

Principle investigator: Dr Bart Vaes
Research Centre: Maria Middelares General Hospital in Ghent

Industrial studies

Industrial studies
  • APPIRED III: Alkaline Phosphatase (RESCAP) for the prevention of perioperative and post-surgical complications after cardiac surgery.

This study aims to determine whether RESCAP can reduce the incidence of kidney-related complications after cardiothoracic surgery.
This study will include high-risk patients undergoing cardiothoracic surgery who require the use of the heart-lung machine.

Study sponsor: Alloksys Life Sciences BV, PW Wageningen, The Netherlands
Phase 3
Local principal investigator: Dr Jan Heerman

  • Ready 1 A phase 3, randomised, double-blind, active and placebo-controlled study on the use of CUSA-081 for dysfunctional central venous catheters.

The purpose of this study is to demonstrate that the product under investigation, CUSA-081, works better than a placebo for restoring function of a blocked central venous catheter.

Study sponsor: IQVIA RDS & Integrated Services NV/SA, Zaventem, Belgium
Phase 3
Local principal investigator: Dr Jan Heerman

  • BLING III: A phase III randomised, controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients.

The patients eligible for this study are critically ill adults with severe infection who need a beta-lactam antibiotic. By comparing continuous and intermittent infusion, we will see if a better outcome is obtained after 90 days.

Study sponsor: The George Institute for Global Health, New South Wales, Australia
Phase 4
Local principal investigator: Dr Jan Heerman